Ohio University gets bragging rights as not only the first university in the state of Ohio (established in 1804), but the oldest university in the U.S. established by federal legislation (aka, the Northwest Ordinance of 1787) before the ratification of the U.S. Constitution in 1790. From its start with one building, three students, and one professor, OHIO now boasts around 30,000 total students. Talk about growth.