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Wilson Administrative, second floor, 204
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Wu Lab Selected Publications

Lingying Tong#, Ye Yuan# and Shiyong Wu*. Therapeutic microRNAs targeting the NF-kappa B Signaling Circuits of Cancers. (Review) Adv Drug Deliv Rev. 2014 (Accepted).

Xiaozhuo Chen, Yanrong Qian, Shiyong Wu*. The Warburg Effect: Evolving Interpretations Of An Established Concept. (Review) Free Radical Biology & Medicine. 2014 (Accepted).

Zheng, Qiuling; Zhang, Hao; Tong, Lingying; Wu, Shiyong; Chen, Hao*.  A New Cross-Linking Electrochemical Mass Spectrometry for Probing Protein 3D-Structures. Anal. Chem. 2014 Aug 20. [Epub ahead of print] PubMed

Lingying Tong and Shiyong Wu*. The Role of Constitutive Nitric Oxide Synthase in UVB-induced NF-κB Activity. J. Biol. Chem. 2014 Aug. 8. [Epub ahead of print] PubMed

Lingying Tong and Shiyong Wu*. ROS and p53 in Regulation of UVB-induced hdm2 Alternative Splicing. Photochem. & Photobio. 2014 Jun 2. [Epub ahead of print] PubMed

Yanrong Qian, Xuan Wang, Yi Liu, Yunsheng Li, Robert Colvin, Lingying Tong, Shiyong Wu, Xiaozhuo Chen*. Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells. Cancer Letter 2014 Sep 1;351(2):242-51. PubMed

Huiwen Cheng, Lei Wang, Molly Mollica, Anthony T. Re, Shiyong Wu*, and Li Zuo*. Nitric oxide in cancer metastasis. (Review) Cancer Letter 2014 Jul 29. [Epub ahead of print] PubMed

Lingying Tong and Shiyong Wu*. ROS and p53 in Regulation of UVB-induced hdm2 Alternative Splicing. Photochem. & Photobio. (2014) Jul 2. [Epub ahead of print] PubMed

Ye Yuan, Michelle L Duff, Dawn L Sammons*, Shiyong Wu. Retrospective chart review of skin cancer presence in the wide excisions. World J Clin Cases (2014) March 16; 2(3): 52-56. PubMed

Shin Hee Lee, Huiwen Cheng, Ye Yuan, and Shiyong Wu*. Regulation of ionizing radiation-induced adhesion of breast cancer cells to fibronectin by alpha5beta1 integrin. Radiation Research (2014) Jun;181(6):650-8. PubMed

Weiwei Yuan, Xuelin Zhang, Yu Xu, Shasha Li, Yide Hu*, and Shiyong Wu*. Role Of HOXB7 In Regulation Of Progression And Metastasis Of Human Lung Adenocarcinoma. Mol. Carcinogenesis 53:49–57 (2014). PubMed

Oliver L. Carpenter and Shiyong Wu*. Regulation of MSK-1-mediated NF-kB Activation Upon UVB Irradiation. Photochem. & Photobio. (2014). 90: 155-61. PubMed.

Huiwen Cheng, Shin Hee Lee and Shiyong Wu*. Effects Of LNAC On Adhesive Strength Between Breast Cancer Cell and Extracellular Matrix Proteins Upon Ionizing Radiation. Life Sciences (2013) 13;93(21):798-803 PubMed

Ye Yuan, Shin Hee Lee and Shiyong Wu*. The Role Of ROS In Ionizing Radiation-Induced VLA-4 Mediated Adhesion Of RAW264.7 Cells To VCAM-1 Under Flow Conditions. Radiation Research (2013) 179, 62–68. PubMed

Lu W and Wu S*. Mechanism for Dynamic Regulation of iNOS Expression After UVB-Irradiation. Mol. Carcinogenesis (2013) 52(8):627-33. PubMed

Huiwen Cheng, Molly Y. Mollica, Shin Hee Lee, Lei Wang, Carlos A. Velázquez-Martínez* and Shiyong Wu*. Effects of Nitric Oxide-Releasing Nonsteroidal Anti-inflammatory Drugs (NONO-NSAIDs) on Melanoma Cell Adhesion. Toxicol Appl Pharmacol. (2012) Oct 15;264(2):161-6. PubMed

Liu Y, Cao Y, Zhang W, Bergmeier SC, Qian Y, Akbar H, Colvin RA, Ding J, Tong L, Wu S, Hines JV, and Chen X*. A small molecule inhibitor of glucose transporter 1 down-regulates glycolysis, induces cell cycle arrest, and inhibits cancer cell growth in vitro and in vivo.  Mol. Cancer Therapeutics (2012) Aug;11(8):1672-82. PubMed

George KS, Elyassaki W, Wu Q and Wu S*. The Role of Cholesterol In Ultraviolet Light B-Induced Apoptosis. Photochem Photobio (2012) 88: 1191–1197. PubMed

Wu Q and Wu S*. Lipid Rafts Association of Prohibitin And Its Role in Ultraviolet B Light -Induced Apoptosis.  Exp. Dermatology (2012) Aug; 21(8):640-2. PubMed

George KS and Wu S*. Lipid Raft: A Floating Island Of Death or Survival. (Invited Review) Toxicol Appl Pharmacol. (2012) 259(3): 311-319. PubMed

Tong L, Heim RA and Wu S*. Nitric Oxide: A Regulator of Eukaryotic Initiation Factor 2 Kinases. Free Radical Biology & Medicine (2011) 50: 1717–1725. Abstract

Wu S*. Targeting expression or function of Plk1 in CTCL, that is a question. Cell Cycle (2011) 10(10) 1526. PubMed.

Parker TA, Cheng HW, Willeford KO and Wu S*. Interleukin-6 Expression In Response To Innate Immune Regulatory Factor Stimulation. Biomedicine & Pharmacotherapy (2011) 65: 90-94. Abstract

Liu W and Wu S*. The Roles of Akt and NOSs In Regulation of VLA-4-Mediated Melanoma Cell Adhesion To Endothelial VCAM-1 After UVB-irradiation. Archives of Biochemistry and Biophysics (2011) 508: 192-197. Abstract

Wang L, Shirure VS, Burdick MM* and Wu S*. UVB-Irradiation Regulates VLA-4-Mediated Melanoma Cell Adhesion To Endothelial VCAM-1 Under Flow Conditions. Mol. Carcinogenesis (2011) 50(1): 58-65. Abstract

Zimmerman AL and Wu S*. MicroRNAs, Cancer and Cancer Stem Cells. (Review) Cancer Letters (2011) 300: 10-19. Abstract

George KS, Wu Q and Wu S*. Effects Of Freezing And Protein Crosslinker On Isolating Membrane Raft Associated Proteins. BioTechniques (2010) 49(5): 837–838. Abstract. PDF Download.

Wu S*. Localization and function of a eukaryotic-initiation-factor-2-associated 67-kDa glycoprotein. World J. Biol. Chem. (2010) 1(10): 313-320. Abstract. PDF Download.

Liu W and Wu S*. Differential Roles of Nitric Oxide Synthases in Regulation of Ultraviolet B Light-induced Apoptosis. Nitric Oxide-Biology and Chemistry (2010), 23(3): 199-205.  Abstract

Wu S* and Tong L. Differential Signaling Circuits In Regulation Of Ultraviolet C Light-Induced Early- And Late-Phase Activation Of NF-kB. (Invited Review) Photochem Photobio. (2010) 86: 995-999. Abstract

Miao Z., Wu S and Chen H*. The Study of Protein Conformation in Solution via Direct Sampling by Desorption Electrospray Ionization Mass Spectrometry. J. Am. Soc. Mass Spectrom. (2010) 21: 1730-1736. Abstract

Wu S*, Wang L, Jacoby A, Jasinski K, Kubant R and Malinski T. Ultraviolet B Light-Induced Nitric Oxide/Peroxynitrite Imbalance in Keratinocytes – Implication in Apoptosis and Necrosis. Photochem Photobio. (2010) 86: 389-396. Abstract.

Wang L, Liu W, Parker SH, and Wu S*. Nitric oxide synthase activation and oxidative stress, but not intracellular zinc dyshomeostasis, regulate ultraviolet B light-induced apoptosis. Life Sciences (2010) 86: 448-454. Abstract.

Wu S* and Carpenter O. L. Coordinative And Dynamic Regulation Of Translation And Transcription By Nitric Oxide And Superoxide Upon Ultraviolet Light Irradiation. Chapter 14 In: Photobiology: Principles, Applications and Effects. Editor: Leon N. Collignon and Claud B. Normand. Nova Science Publishers, Inc. (2010) 251-267. PDF Download

Liu Y, Laszlo CF, Liu Y, Liu W, Chen X, Evans SC and Wu S*. Regulation of G1 Arrest and Apoptosis under Hypoxia by PERK and GCN2-mediated eIF2a Phosphorylation. Neoplasia (2010) 12(1): 61-68. Abstract. PDF Download.

Wang L, Liu Y and Wu S*. The Roles of Nitric Oxide Synthase and eIF2alpha Kinases in Regulation of Cell Cycle Upon UVB-irradiation. Cell Cycle (2010) 9(1): 38-43. Abstract.

Wu S*. New Life for an _Old_ Drink. Cell Cycle (2009) 8(13): 1979-80. View.

Lu W, Laszlo CF, Miao Z, Chen H and Wu S*. The Role of Nitric Oxide Synthase in Regulation of Ultraviolet Light-induced Phosphorylation of the Alpha-subunit of Eukaryotic Initiation Factor 2. J. Biol. Chem. (2009) 284(36): 24281-24288. Abstract.

Laszlo CF, Fayads S, George KS, Carpenter OL, Lu W, Saad AA and Wu S*. _The Roles Of Translation Regulation In Ultraviolet Light-Induced COX 2 Expression_. Life Sciences (2009) 85: 70-76. Abstract.

Laszlo CF and Wu S*. Old Target New Approach: Translation Inhibition an Alternate NF-kappaB Activation Pathway. Mol Cell Biochem. (2009) 328:9–16. Abstract.

Laszlo CF and Wu S*. Mechanism of UV-Induced IkappaBalpha-Independent Activation of NF-kappaB. Photochem Photobio. (2008) 84: 1564–1568. Abstract.

Parker SH, Parker TA, George KS and Wu S*. The Roles Of Translation Initiation Regulation In Ultraviolet Light-Induced Apoptosis. Mol Cell Biochem. (2006) 293(1-2): 173-81. Abstract.

Elyassaki W. and Wu, S*. _Lipidrafts mediates ultra-violet light-induced FAS aggregation in M624 melanoma cells_. Photochem. & Photobio. (2006) 82: 787-792. Abstract.

Parker TA, Willeford KO, Pharr GT, Hebert P, Pruett SB and Wu S * (2005) An Innate Immune Regulatory Factor (IIRF) Prevents Tumorogenesis in a Murine Melanoma Challenge Model. Drug Dev. Res. 2005; 64:213-219. Abstract.

Wu, S.*, Tan, M., Hu, Y., Wang, J. Scheuner, D. and Kaufman, R. J. (2004). Ultraviolet light induces early-phase NFkB activation through translational inhibition of IkB synthesis J. Biol. Chem. 279(33):34898-34902. Abstract.

Wu, S. and Kaufman, R. J.* (2004). Trans-autophosphorylation of PKR in the Absence of dsRNA is not Sufficient for PKR Dimerization or Activation. Biochemistry 43(34):11027-34. Abstract.

Wu, S.,* Hu, Y., Wang, J., Chatterjee, M., Shi, Y. and Kaufman, R. J. (2002) Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum. J. Biol. Chem. 277, 18077-18083. Abstract.

Wu, S., Loke, H. N. and Rehemtulla, A* (2002) Ultraviolet Radiation-Induced Apoptosis Is Mediated by Daxx. Neoplasia 4, 486-492. Abstract.

Chatterjee, M. and Wu, S.* (2001). Involvement of Fas receptor and not tumor necrosis factor-alpha receptor in ultraviolet-induced activation of acid sphingomyelinase. Mol. Carcinogenesis. 30, 47-55. Abstract.

Chatterjee, M. and Wu, S.* (2001). Cell Line Dependent Involvement Of Ceramide In Ultraviolet Light-Induced Apoptosis. Mol. Cell. Biochem. 219, 21-27. Abstract.

Wang, J., Sun, Y., and Wu, S.* (2000). Gamma-irradiation Induces Matrix Metalloproteinase II (MMP 2) Expression in a p53 Dependent Manner. Mol. Carcinogenesis. 4, 252-258. Abstract.

Wu, S., Kumar, K. U. and Kaufman, R. J.* (1998). Identification and importance of the ribosome binding domains of the dsRNA-dependent Protein Kinase (PKR). Biochemistry 29, 13816-13826. Abstract.

Wu, S. and Kaufman, R. J.* (1997). A Model for the Double-stranded (ds) RNA-Dependent Dimerization and Activation of the dsRNA-dependent Protein Kinase (PKR). J. Biol. Chem. 272, 1291-1296. Abstract.

Wu, S. and Kaufman, R. J.* (1996). Double-stranded RNA Binding Is Repuired And Dimeriaztion Is Not Sufficient for the Activation of the dsRNA-dependent Protein Kinase (PKR). J. Biol. Chem. 271, 1756-1763. Abstract.

Wu, S., Rehemtulla, A., Gupta, N. K. and Kaufman, R. J.* (1996). An eIF-2 Associated 67 kDa Glycoprotein (p67) Partially Reverses Protein Synthesis Inhibition by Activated Double-stranded RNA Depentdent Protein Kinase (PKR) in Intact Cells. Biochem. 35, 8275-8250. Abstract.