Helpful Links

Navigate OHIO

About OHIO Admission Athletics
Academics Life at OHIO

Connect With Us

Ohio University Heritage College of Osteopathic Medicine
Heritage Hall, Athens, OH 45701
Directions

Shouan Zhu, PhD

Shouan Zhu 8-2020
Associate Professor, Osteopathic Heritage Foundation Ralph S. Licklider, D.O. Endowed Professor
Life Science Building
Biomedical Sciences
Diabetes Institute
Ohio Musculoskeletal and Neurological Institute
Athens
zhus1@ohio.edu
OpenScholar

Education:

  • Aging and Metabolism, Oklahoma Medical Research Foundation (Postdoc), 2020
  • Orthopedics research, Johns Hopkins University (Postdoc), 2017
  • Orthopedics research, Johns Hopkins University (PhD, 4, 5 year), 2016
  • Stem cell and regenerative medicine (PhD, 1, 2, 3 year), Zhejiang University, 2014

Summary of Work: 

We are studying how osteoarthritis (OA) occurs with different risk factors, such as aging and obesity, with particular interests in studying the role of cellular metabolism in OA pathogenesis.

Our recent findings demonstrate that one type of protein post-translational modification-lysine malonylation (MaK) is increased during aging and obesity and promotes chondrocyte metabolic dysfunction. Additionally, the demalonylase SIRT5 decreases in cartilage during aging. The current active research projects in lab include: 1. Studying how an aging-dependent decline of Sirt5 promotes MaK and chondrocyte metabolic dysfunction; 2. Studying how MaK is accumulated in cartilage during obesity.

Links:

View My LinkedIn: https://www.ncbi.nlm.nih.gov/myncbi/1zsycoDw_izAc/bibliography/public/

View My Lab/Research Website: https://www.ohio.edu/medicine/omni/labs/osteoarthritis-research and https://people.ohio.edu/zhus1/

View My Work in ResearchGate: https://www.researchgate.net/profile/Shouan-Zhu-2

View My Work in Google Scholar: https://scholar.google.com/citations?user=5DPLUl4AAAAJ